This Call to Action from GCOA’s Aging with Heart Alliance urges UN Member States to address the global impact of cardiovascular disease (CVD)–the leading cause of death worldwide—within the context of rapid population aging. With CVD prevalence and associated costs rising sharply with age, the document outlines a four-part agenda: expand prevention across the full continuum of care; strengthen access to early detection and community-based treatment; invest in innovation and health system transformation; and empower patients through integrated care models. Released ahead of the 2025 UN High-Level Meeting on NCDs and Mental Health, the report emphasizes that prioritizing CVD is essential to achieving healthy aging, health equity, and long-term global health and economic resilience.