In May 2021, the Global Coalition on Aging (GCOA) and the Health and Global Policy Institute (HGPI) hosted a second joint roundtable on the challenges of antimicrobial resistance (AMR) in super-aging Japan. The roundtable brought together Japanese and global experts in aging and infectious disease, examining in particular the coupled crises of antimicrobial resistance (AMR) and a lack of antibiotic innovation. In November 2021, the two organizations issued a report, “Taking Action for AMR Preparedness: Spurring Antibiotic Innovation for Healthy Ageing in Super-Ageing Japan,” based on the key findings from the roundtable. The report outlines the impact of AMR on older adults and the dire consequences for fiscal sustainability and economic growth while offering a roadmap for urgent action.